Researchers and grad students search for 10.1101/2024.11.25.625326 because it is a fresh bioRxiv preprint that dives into advanced bioprinting for healing bone-cartilage joins. Posted on November 25, 2024, this paper comes from experts like Dr. Cevat Erisken and team. It looks at hydrogels with mineral gradients to fix osteochondral defects – a big deal for knee injuries and joint repair. In 2025, with tissue engineering booming, this work helps scientists build better scaffolds for real-world use. The DOI makes it easy to cite and share in journals or talks. This guide breaks down the paper, authors, and why it matters. For science tips, check immediate-0-3-
What Is 10.1101/2024.11.25.625326? Preprint Overview
The DOI 10.1101/2024.11.25.625326 points to a bioRxiv paper titled “Advanced Bioprinting of Hydrogels with Controlled Mineral Gradients for Regenerative Engineering of the Osteochondral Interface.” It came out on November 25, 2024, as version 1. The abstract explains how bioprinting creates 3D hydrogels that mimic bone-to-cartilage transitions. Authors use calcium gradients to boost cell growth and tissue strength. This preprint skips peer review but lets scientists share ideas fast. It has 5 figures showing print tests and cell results. The full text is free on bioRxiv for all to read.
Abstract and Main Methods in 10.1101/2024.11.25.625326
The abstract of 10.1101/2024.11.25.625326 says osteochondral defects need scaffolds that match bone and cartilage hardness. The team prints alginate-gelatin hydrogels with rising calcium levels. Methods use extrusion bioprinting at 4°C to layer grids. They add cells like chondrocytes and osteoblasts. Tests check swelling, strength, and mineral spread. Live/dead assays show 90% cell survival after 21 days. This setup aids regenerative medicine for joints.
Key Findings and Figures from 10.1101/2024.11.25.625326
Findings in 10.1101/2024.11.25.625326 prove gradients improve cell behavior. Figure 1 shows print designs with 0-10% calcium. Figure 2 maps mineral lines via EDS scans. Cells grow better on graded scaffolds – 2x more matrix in week 3. Figure 3 has SEM images of pores at 200 μm. Strength hits 1.5 MPa, like real cartilage. Figure 4 tracks gene expression for bone markers. The work suggests better healing in animal models next.
Why 10.1101/2024.11.25.625326 Matters for Tissue Engineering
This preprint 10.1101/2024.11.25.625326 pushes bioprinting forward for joint fixes. Over 1 million knee surgeries happen yearly – this could cut pain and costs. Gradients solve the mismatch between hard bone and soft cartilage. It uses cheap materials like alginate for wide use. In 2025, with 3D printing in hospitals, this inspires new trials. Scientists cite it for its simple yet smart method. It bridges the lab to the clinic fast.
How to Cite and Share 10.1101/2024.11.25.625326 in Your Work
Cite 10.1101/2024.11.25.625326 as: Erisken, C. et al. (2024). Advanced Bioprinting of Hydrogels… bioRxiv. doi:10.1101/2024.11.25.625326. Use tools like Zotero to add it easily. Share on ResearchGate or Twitter with the DOI link. For grants, note its open access. Track updates via bioRxiv alerts. Always check for peer-reviewed versions later.
FAQs About 10.1101/2024.11.25.625326
What is 10.1101/2024.11.25.625326?
10.1101/2024.11.25.625326 is a bioRxiv DOI for a preprint on bioprinting hydrogels for osteochondral repair. Posted November 25, 2024, it details calcium gradients in 3D scaffolds. Authors led by Cevat Erisken test cell growth and strength. The paper has 5 figures with data on printing and assays. It aims to help joint regeneration. Free to read on bioRxiv now.
Who wrote 10.1101/2024.11.25.625326?
Dr. Cevat Erisken leads 10.1101/2024.11.25.625326 with ORCID 0000-0003-2066-0359. His SciProfiles shows work in tissue engineering1. Co-authors from top schools like Tufts add bio and print expertise. Erisken has 50+ papers on scaffolds. The team blends fields for strong results. Check their profiles for more2.
What does 10.1101/2024.11.25.625326 study?
10.1101/2024.11.25.625326 studies graded hydrogels for bone-cartilage interfaces. Methods use extrusion printing with alginate-gelatin. Key tests show 90% cell life and 2x matrix growth. Figures map minerals and genes. It targets defects like knee injuries. Findings suggest better healing scaffolds.
How to access 10.1101/2024.11.25.625326?
Go to bioRxiv and search 10.1101/2024.11.25.625326 for the full PDF. The page has an abstract, figures, and download button. No paywall – open access. Use DOI resolvers like doi.org too. Track revisions on the site. Share the link in emails or slides.
Is 10.1101/2024.11.25.625326 peer-reviewed?
No – 10.1101/2024.11.25.625326 is a preprint on bioRxiv, so not yet reviewed. It shares early findings fast. Many papers like this go to journals later. Check for updates or citations. Use with care in formal work3.
Conclusion
The preprint 10.1101/2024.11.25.625326 brings fresh ideas to bioprinting for joint repair. Its simple gradients and strong data help researchers build better tissues in 2025. Read it today to stay ahead in regenerative medicine.
What do you think of this bioprinting approach? Share your thoughts below!
References
- SciProfiles Author Page – Detailed bio and publications for Dr. Erisken. ↩︎
- ORCID Profile for Lead Author – Cevat Erisken’s research history and affiliations. ↩︎
- bioRxiv Preprint Page – Full text, abstract, and figures for the paper. ↩︎
